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Signaling Pathway

mTOR signaling pathway

Font Size: [Big][Mid][Small] 2020-9-23    Views: 21    

The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.


Genes:

SLC7A5, SLC3A2, SLC38A9, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C2, ATP6V1C1, ATP6V1D, ATP6V1E2, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G3, ATP6V1G2, ATP6V1H, LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, LAMTOR5, FLCN, FNIP1, FNIP2, RRAGA, RRAGB, RRAGC, RRAGD, SESN2, CASTOR1, CASTOR2, MIOS, SEH1L, WDR24, WDR59, SEC13, DEPDC5, NPRL2, NPRL3, SKP2, RNF152, RPTOR, AKT1S1, MTOR, DEPTOR, MLST8, TELO2, TTI1, CLIP1, GRB10, LPIN1, LPIN3, LPIN2, ULK1, ULK2, EIF4EBP1, EIF4E, EIF4E2, EIF4E1B, RPS6KB1, RPS6KB2, EIF4B, RPS6, STRADA, STRADB, STK11, CAB39, CAB39L, PRKAA1, PRKAA2, TSC1, TSC2, TBC1D7, RHEB, DDIT4, WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, WNT10B, WNT10A, WNT11, WNT16, FZD1, FZD7, FZD2, FZD3, FZD4, FZD5, FZD8, FZD6, FZD10, FZD9, LRP5, LRP6, DVL3, DVL2, DVL1, GSK3B, TNF, TNFRSF1A, IKBKB, INS, IGF1, INSR, IGF1R, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, BRAF, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, RPS6KA3, RPS6KA1, RPS6KA2, RPS6KA6, IRS1, PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB, PTEN, PDPK1, AKT1, AKT2, AKT3, CHUK, MAPKAP1, RICTOR, PRR5, RHOA, PRKCA, PRKCB, PRKCG, SGK1

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