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Signaling Pathway

PI3K-Akt signaling pathway

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The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.


Genes:

EGF, TGFA, EREG, AREG, FGF1, FGF2, FGF3, FGF4, FGF17, FGF6, FGF7, FGF8, FGF9, FGF10, FGF16, FGF5, FGF18, FGF20, FGF22, FGF19, FGF21, FGF23, NGF, BDNF, NTF3, NTF4, INS, IGF1, IGF2, PDGFA, PDGFB, PDGFC, PDGFD, CSF1, KITLG, FLT3LG, VEGFA, VEGFB, PGF, VEGFC, VEGFD, HGF, ANGPT1, ANGPT2, ANGPT4, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EGFR, ERBB2, ERBB3, ERBB4, FGFR1, FGFR2, FGFR3, FGFR4, NGFR, NTRK1, NTRK2, INSR, IGF1R, PDGFRA, PDGFRB, CSF1R, KIT, FLT3, FLT1, FLT4, KDR, MET, TEK, EPHA2, GRB2, SOS1, SOS2, HRAS, KRAS, NRAS, RAF1, MAP2K1, MAP2K2, MAPK1, MAPK3, IRS1, TLR2, TLR4, RAC1, IGH, SYK, CD19, PIK3AP1, GH1, GH2, CSH1, CSH2, PRL, OSM, IL2, IL3, IL6, IL4, IL7, IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, EPO, CSF3, GHR, PRLR, OSMR, IL2RA, IL2RB, IL2RG, IL3RA, IL6R, IL4R, IL7R, IFNAR1, IFNAR2, EPOR, CSF3R, JAK1, JAK2, JAK3, COL1A1, COL1A2, COL2A1, COL4A2, COL4A4, COL4A6, COL4A1, COL4A5, COL4A3, COL6A1, COL6A2, COL6A3, COL6A6, COL6A5, COL9A1, COL9A2, COL9A3, LAMA1, LAMA2, LAMA3, LAMA5, LAMA4, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, CHAD, RELN, THBS1, COMP, THBS2, THBS3, THBS4, FN1, SPP1, VTN, TNC, TNN, TNR, TNXB, VWF, IBSP, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGA10, ITGA11, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, PTK2, PIK3CA, PIK3CD, PIK3CB, PIK3R1, PIK3R2, PIK3R3, F2R, CHRM1, CHRM2, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, GNB1, GNB2, GNB3, GNB4, GNB5, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, GNGT1, GNGT2, PIK3CG, PIK3R5, PIK3R6, PDPK1, STK11, PRKAA1, PRKAA2, DDIT4, TSC1, TSC2, RHEB, MLST8, MTOR, RPTOR, EIF4EBP1, EIF4E, EIF4E2, EIF4E1B, RPS6KB1, RPS6KB2, EIF4B, RPS6, PRKCA, PKN1, PKN2, PKN3, SGK1, SGK2, SGK3, C8orf44-SGK3, AKT1, AKT2, AKT3, MAGI1, MAGI2, PTEN, THEM4, PPP2CA, PPP2CB, PPP2R1B, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R2D, PPP2R3B, PPP2R3C, PPP2R3A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, PPP2R5A, HSP90AA1, HSP90AB1, HSP90B1, CDC37, CRTC2, PHLPP1, PHLPP2, TCL1A, TCL1B, MTCP1, NOS3, BRCA1, GSK3B, GYS2, GYS1, PCK1, PCK2, G6PC, G6PC2, G6PC3, MYC, CCND1, CDKN1A, CDKN1B, CDK2, CDK4, CDK6, CCND2, CCND3, CCNE1, CCNE2, FOXO3, RBL2, FASLG, BCL2L11, YWHAZ, YWHAB, YWHAQ, YWHAE, YWHAH, YWHAG, BAD, BCL2L1, BCL2, CASP9, CREB1, ATF2, ATF4, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, ATF6B, MCL1, RXRA, NR4A1, IKBKG, CHUK, IKBKB, RELA, NFKB1, MYB, MDM2, TP53

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