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Signaling Pathway

BMP signaling pathway

Font Size: [Big][Mid][Small] 2020-9-23    Views: 20    

The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.


Genes:

CHRD, NOG, NBL1, MICOS10-NBL1, GREM1, GREM2, THBS1, DCN, FMOD, LEFTY1, LEFTY2, FST, BMP2, BMP4, BMP6, INHBB, BMP5, BMP7, BMP8B, BMP8A, GDF5, GDF6, GDF7, AMH, THSD4, FBN1, LTBP1, TGFB1, TGFB2, TGFB3, INHBA, INHBC, INHBE, NODAL, NEO1, HJV, BMPR1A, BMPR1B, ACVR1, BMPR2, ACVR2A, RGMA, RGMB, AMHR2, TGFBR1, TGFBR2, ACVR1B, ACVR2B, ACVR1C, BAMBI, SMAD1, SMAD5, SMAD9, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMURF1, SMURF2, ZFYVE9, ZFYVE16, HAMP, ID1, ID2, ID3, ID4, RBL1, E2F4, E2F5, TFDP1, CREBBP, EP300, SP1, TGIF1, TGIF2, MYC, CDKN2B, PITX2, RBX1, CUL1, SKP1, MAPK1, MAPK3, IFNG, TNF, RHOA, ROCK1, PPP2R1B, PPP2R1A, PPP2CA, PPP2CB, RPS6KB1, RPS6KB2

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