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Signaling Pathway

NF-κB signaling pathway

Font Size: [Big][Mid][Small] 2020-9-23    Views: 19    

Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.


Genes:

LCK, ZAP70, LAT, PLCG1, PRKCQ, IGH, SYK, LYN, BLNK, BTK, PLCG2, PRKCB, CARD10, CARD11, CARD14, BCL10, MALT1, IL1B, IL1R1, MYD88, IRAK1, IRAK4, TRAF6, TNF, TNFRSF1A, RIPK1, TRADD, TRAF2, TRAF5, BIRC2, BIRC3, EDA, EDAR, EDARADD, CYLD, EDA2R, DDX58, TRIM25, LBP, CD14, TLR4, LY96, TIRAP, TICAM2, TICAM1, CD40LG, CD40, TRAF3, TNFSF11, TNFRSF11A, LTA, LTB, TNFSF14, LTBR, MAP3K14, MAP3K7, TAB1, TAB2, TAB3, TNFSF13B, TNFRSF13C, IKBKG, CHUK, IKBKB, PARP1, PIAS4, UBE2I, ATM, PIDD1, ERC1, NFKBIA, NFKB1, RELA, CFLAR, XIAP, BCL2L1, BCL2, GADD45A, GADD45B, GADD45G, TRAF1, BCL2A1, NFKB2, CXCL8, TNFAIP3, PTGS2, CCL4, CCL4L2, CCL4L1, CXCL1, CXCL2, CXCL3, VCAM1, PLAU, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, RELB, CCL13, CCL19, CCL21, CXCL12, ICAM1

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