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Endometrial cancer

Font Size: [Big][Mid][Small] 2016-3-23    Views: 438    

Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb). In 2012, endometrial cancers occurred in 62 thousand women in China and the projected cases in 2016 are 81 thousand. This makes it, together with ovarian and cervical cancer, one of the three most common cancers which only affect women. It is more common in the developed world and is the most common cancer of the female reproductive tract in developed countries.

The vast majority of endometrial cancers are carcinomas (usually adenocarcinomas) that are broadly organized into two categories, Type I and Type II, based on clinical features and pathogenesis. Type I endometrial carcinomas occur most commonly before and around the time of menopause. Type I endometrial cancers are often low-grade, minimally invasive into the underlying uterine wall (myometrium), estrogen-dependent, and have a good outcome with treatment. Type I carcinomas represent 75–90% of endometrial cancer. Type II endometrial carcinomas usually occur in older, post-menopausal people, are not associated with increased exposure to estrogen or a history of endometrial hyperplasia. Type II endometrial cancers are often high-grade, with deep invasion into the underlying uterine wall (myometrium), are of the serous or clear cell type, and carry a poorer prognosis.

Gene expression profiles have been collected and molecular diagnostic product for endometrial cancer is under development.









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